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Showing 1–6 of 6 results
Advanced filters: Author: Jonathan Soboloff Clear advanced filters

  • Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca2+ entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.

    • Robert Hooper
    • Jonathan Soboloff
    News & Views
    Nature Cell Biology
    Volume: 17, P: 1232-1234

  • STIM proteins sense subtle changes in the levels of endoplasmice reticulum (ER)-stored Ca2+ and respond by regulating extracellular Ca2+entry and cell signalling. New structural and functional data have shed light on the role of STIM proteins as stress sensors.

    • Jonathan Soboloff
    • Brad S. Rothberg
    • Donald L. Gill
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 549-565

  • STIM proteins are key regulators of intracellular Ca2+ signalling. Here, Wang et al. demonstrate that subtle differences between STIM1 and its close homologue STIM2 have profound consequences for their ability to gate Orai1 Ca2+channels, thus revealing the basis for their distinct physiological functions.

    • Xizhuo Wang
    • Youjun Wang
    • Donald L Gill
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.

    • Shan He
    • Yongnian Liu
    • Yi Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.

    • Jonathan Soboloff
    • Muniswamy Madesh
    • Donald L Gill
    Comments & Opinion
    Nature Chemical Biology
    Volume: 7, P: 488-492