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Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency

Holger Prokisch and colleagues report whole-exome sequencing of an individual with severe complex I deficiency, followed by screening in an additional 120 cases. They identify mutations in ACAD9 as causal for complex I deficiency.

Tobias B Haack
Katharina Danhauser
Holger Prokisch
Research07 Nov 2010
Nature Genetics

Volume: 42, P: 1131-1134
LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

SARS-CoV-2 detection with LAMP-Seq combines isothermal amplification and barcoding with high-throughput sequencing.

Kerstin U. Ludwig
Ricarda M. Schmithausen
Jonathan L. Schmid-Burgk
Research29 Jun 2021
Nature Biotechnology

Volume: 39, P: 1556-1562
Engineering of CRISPR-Cas12b for human genome editing

The Cas12b family of CRISPR nucleases has been underutilized in mammalian cells due to the high temperature requirement of known members. Here the authors engineer BhCas12b to overcome this limitation for robust and specific genome editing applications in human cells.

Jonathan Strecker
Sara Jones
Feng Zhang
ResearchOpen Access22 Jan 2019
Nature Communications

Volume: 10, P: 1-8
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

Damaged DNA is often targeted to nuclear pore complexes for repair. Here, the authors show that kinesin-14 mediates this process ensuring error-prone repair, while perinuclear telomere attachment licenses damaged telomeric loci for this repair and kinesin-14 blocks senescence in the absence of telomerase.

Daniel K.C. Chung
Janet N.Y. Chan
Karim Mekhail
Research24 Jul 2015
Nature Communications

Volume: 6, P: 1-13
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

Kerstin U. Ludwig
Ricarda M. Schmithausen
Jonathan L. Schmid-Burgk
Amendments and Corrections18 Jul 2022
Nature Biotechnology

Volume: 40, P: 1295
DNA damage signalling targets the kinetochore to promote chromatin mobility

Durocher and colleagues find that in budding yeast, the movement of chromosomes induced by DNA breaks is due to the loss of attachment of kinetochores to spindle pole bodies and of telomeres to the nuclear periphery, and may promote checkpoint arrest.

Jonathan Strecker
Gagan D. Gupta
Daniel Durocher
Research01 Feb 2016
Nature Cell Biology

Volume: 18, P: 281-290
Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

Following DNA damage, different processes come to action to aid repair. The authors here find that microtubule filaments within the cell nucleus capture and non-randomly mobilize damaged chromatin to mediate DNA repair.

Roxanne Oshidari
Jonathan Strecker
Karim Mekhail
ResearchOpen Access02 Jul 2018
Nature Communications

Volume: 9, P: 1-11
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks

Edward F. Pace-Schott
J. Allan Hobson
Reviews01 Aug 2002
Nature Reviews Neuroscience

Volume: 3, P: 591-605
Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity

Helena Müller
Sarah Katharina Fehling
Thomas Strecker
ResearchOpen Access04 Aug 2020
npj Vaccines

Volume: 5, P: 1-17

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Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

Engineering of CRISPR-Cas12b for human genome editing

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

DNA damage signalling targets the kinetochore to promote chromatin mobility

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks

Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity

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