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Showing 1–2 of 2 results
Advanced filters: Author: Jonathan T. Sockolosky Clear advanced filters

  • In contrast to their clinical success as inhibitors and targeting agents, antibodies have generally been ineffective as receptor agonists. Here, Romei et al. leverage a natural homotypic interface to tune antibody geometry, enabling optimization of agonist activity for multiple therapeutic targets.

    • Matthew G. Romei
    • Brandon Leonard
    • Greg A. Lazar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Existing in vivo mutagenesis tools are limited by low mutation diversity and mutation rates. Here the authors present TRIDENT for targeted, continual and inducible diversification of genes of interest using deaminases fused to T7 RNA polymerase.

    • Aaron Cravens
    • Osman K. Jamil
    • Christina D. Smolke
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12