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Showing 1–4 of 4 results
Advanced filters: Author: Jonathon L. Burman Clear advanced filters

  • The PINK1 ubiquitin kinase is shown to recruit the two autophagy receptors NDP52 and OPTN to mitochondria to activate mitophagy directly, independently of the ubiquitin ligase parkin; once recruited to mitochondria, NDP52 and OPTN recruit autophagy initiation components, and parkin may amplify the phospho-ubiquitin signal generated by PINK1, resulting in robust autophagy induction.

    • Michael Lazarou
    • Danielle A. Sliter
    • Richard J. Youle
    Research
    Nature
    Volume: 524, P: 309-314

  • Alterations in mitochondrial function, which are amplified by defective mitochondrial quality control (MQC) mechanisms, are major contributing factors to cardiac senescence. In this Review, the authors discuss the mechanisms linking defective MQC to organelle dysfunction in the context of cardiac ageing and consider how these pathways might be targeted for the prevention and treatment of age-related heart dysfunction.

    • Anna Picca
    • Robert T. Mankowski
    • Christiaan Leeuwenburgh
    Reviews
    Nature Reviews Cardiology
    Volume: 15, P: 543-554