Arfaxad Reyes-Alcaraz et al. report that galanin induces robust signaling mediated by β-arrestin1/2 and Gαq, whereas an alternative ligand spexin prefers the Gαq-protein signaling pathway. This study provides mechanistic insights into how endogenous ligands can generate biased signaling outputs.
- Arfaxad Reyes-Alcaraz
- Yoo-Na Lee
- Jae Young Seong
