Nature Search

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

The multidomain scaffold protein SH3 and multiple ankyrin repeat domain 3 (SHANK3) can bind GTP-bound Ras and Rap small GTPases. Here the authors show that, by binding active KRAS, SHANK3 maintains oncogenic KRAS/MAPK/ERK signaling at an optimal level while its depletion in KRAS-mutant cancer cell lines results in ERK signalling overdose and impaired cell proliferation.

Johanna Lilja
Jasmin Kaivola
Johanna Ivaska
ResearchOpen Access12 Sept 2024
Nature Communications

Volume: 15, P: 1-20
Context-dependent decision-making in the primate hippocampal–prefrontal circuit

The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value subcircuits via theta synchronization.

Thomas W. Elston
Joni D. Wallis
ResearchOpen Access06 Jan 2025
Nature Neuroscience

Volume: 28, P: 374-382
Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex

Working memory (WM) is represented in persistent activity of single neurons as well as a dynamic population code. Here, the authors find that neurons flexibly switch their coding according to current attention while those with stable resting activity maintain WM representations through dynamic activity patterns.

Sean E. Cavanagh
John P. Towers
Steven W. Kennerley
ResearchOpen Access29 Aug 2018
Nature Communications

Volume: 9, P: 1-16
Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer

Here, the authors present a comparative analysis of the diet, microbiome and metabolome of rural and urban Xhosa people in South Africa, associating urban diets with higher abundances of pro-neoplastic microbial metabolites.

M. C. Ramaboli
S. Ocvirk
S. J. D. O’Keefe
ResearchOpen Access20 Apr 2024
Nature Communications

Volume: 15, P: 1-12
Value dynamics affect choice preparation during decision-making

During decision-making, neurons in the orbitofrontal cortex flip-flop between representing the value of alternative options, which influences ramping signals in the downstream anterior cingulate cortex that encode the choice response.

Zuzanna Z. Balewski
Thomas W. Elston
Joni D. Wallis
Research10 Aug 2023
Nature Neuroscience

Volume: 26, P: 1575-1583
Spatiotemporal dynamics of information encoding revealed in orbitofrontal high-gamma

High gamma activity (HGA) and local neurons encode similar information, but it’s unclear if this is true when neurons are heterogeneous, as in the orbitofrontal cortex (OFC). Here, Rich & Wallis show that HGA in OFC is closely related to neuron firing, but reveals clearer spatiotemporal dynamics.

Erin L. Rich
Joni D. Wallis
ResearchOpen Access26 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Taking stock of value in the orbitofrontal cortex

The orbitofrontal cortex (OFC) has long been thought to track value, but new data implicate the OFC in the representation of cognitive maps of associative relationships. Here, Knudsen and Wallis review these hypotheses and examine how they might be reconciled.

Eric B. Knudsen
Joni D. Wallis
Reviews25 Apr 2022
Nature Reviews Neuroscience

Volume: 23, P: 428-438
GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function

Joni Haikonen
Rakenduvadhana Szrinivasan
Sari E. Lauri
ResearchOpen Access28 Jun 2024
Molecular Psychiatry

Volume: 29, P: 3752-3768
Distributional reinforcement learning in prefrontal cortex

Muller et al. show that some neurons in the cortex learn faster from better-than-expected outcomes compared to worse-than-expected ones; others do the converse, resulting in simultaneous optimism and pessimism, as predicted by distributional reinforcement learning.

Timothy H. Muller
James L. Butler
Steven W. Kennerley
ResearchOpen Access10 Jan 2024
Nature Neuroscience

Volume: 27, P: 403-408
Improving the anti-ageing activity of coenzyme Q10 through protransfersome-loaded emulgel

Qurrota Ayunin
Andang Miatmoko
Djoko Legowo
ResearchOpen Access18 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Parameterizing neural power spectra into periodic and aperiodic components

A method for parameterizing electrophysiological neural power spectra into periodic and aperiodic components is introduced, addressing limitations of common approaches. The method is validated in simulation and demonstrated on real data applications.

Thomas Donoghue
Matar Haller
Bradley Voytek
Research23 Nov 2020
Nature Neuroscience

Volume: 23, P: 1655-1665
Distinct neural representations during a brain–machine interface and manual reaching task in motor cortex, prefrontal cortex, and striatum

Ellen L. Zippi
Gabrielle F. Shvartsman
Jose M. Carmena
ResearchOpen Access19 Oct 2023
Scientific Reports

Volume: 13, P: 1-17
Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

Thomas M. O’Shea
Robert M. Joseph
Kelly Vogt
Research29 May 2018
Journal of Perinatology

Volume: 38, P: 908-916

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