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Showing 1–3 of 3 results
Advanced filters: Author: Jonna Saarimäki-Vire Clear advanced filters

  • The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cell cytotoxicity; representing a potent therapeutic target to halt T1D progression.

    • Vikash Chandra
    • Hazem Ibrahim
    • Timo Otonkoski
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Loss-of-function mutations in primate-specific ZNF808 cause pancreatic agenesis. Mechanistically, the loss of ZNF808 leads to the activation of the MER11 family of transposable elements in a regulatory capacity that ultimately induces a liver-specific program of gene expression during pancreatic differentiation.

    • Elisa De Franco
    • Nick D. L. Owens
    • Michael Imbeault
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 2075-2081