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Showing 1–2 of 2 results
Advanced filters: Author: Jordan Blondelle Clear advanced filters

  • Blondelle & Marrocco et al. show that deletion of both Obsl1 and obscurin in skeletal muscle leads to severe alterations in sarcolemma organization, protein expression profiles, and cellular calcium handling. These alterations affected muscle physiology and suggest redundant roles for Obsl1 and obscurin in murine muscle function.

    • Jordan Blondelle
    • Valeria Marrocco
    • Stephan Lange
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-13

  • Altered function of the muscle LIM protein (MLP) causes dilated cardiomyopathy in mice and humans. Lange et al. explain the molecular role of MLP in the heart by showing that it affects the signalling complex at the intercalated discs of failing hearts that consists of PKCα, PLCβ1 and CARP by inhibiting PKCα auto-phosphorylation and function.

    • Stephan Lange
    • Katja Gehmlich
    • Elisabeth Ehler
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11