Nature Search

Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging

The role of olfactory pathways in the development of neurodegeneration in Alzheimer’s disease is not well understood. Here, the authors show odor identification deficits are predictive of tau accumulation and progression in olfactory pathways, and that tau spreads from medial temporal lobe structures towards the olfactory system.

Ibai Diez
Laura Ortiz-Terán
Jorge Sepulcre
ResearchOpen Access06 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition

In vivo human neuroimaging shows that locus coeruleus (LC) integrity changes precede medial temporal tau accumulation, and jointly predict future lower cognition in older people at risk for Alzheimer’s disease. A common transcriptomic profile underlies LC’s early vulnerability to tau.

Elisenda Bueichekú
Ibai Diez
Heidi I. L. Jacobs
ResearchOpen Access25 Apr 2024
Nature Aging

Volume: 4, P: 625-637
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.

Jorge Sepulcre
Michel J. Grothe
Keith A. Johnson
Research29 Oct 2018
Nature Medicine

Volume: 24, P: 1910-1918
College education as a modulator of the aging brain

What makes some human brains more resilient to aging than others? In an Article in Nature Aging, Chan et al. provide evidence that brain connectomes in older adults are altered by a college education — an environmental factor that might be an advantageous modulator of brain reserve during aging.

Jorge Sepulcre
News & Views11 Nov 2021
Nature Aging

Volume: 1, P: 980-981
Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain

Attractor dynamics have been discovered in neural circuits, but it is not clear if they exist at the level of whole-brain activity. Here, the authors show that certain brain regions act as nodes in which many activity ‘streams’ converge, regardless of brain state. These regions show distinctive gene expression.

Ibai Diez
Jorge Sepulcre
ResearchOpen Access24 Sept 2018
Nature Communications

Volume: 9, P: 1-10
Connectivity adaptations in dopaminergic systems define the brain maturity of investors

Elena Ortiz-Teran
Ibai Diez
Tomas Ortiz
ResearchOpen Access03 Jun 2021
Scientific Reports

Volume: 11, P: 1-7
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

Using longitudinal multimodal imaging data collected in healthy older individuals, Jacobs et al. provide in vivo evidence in humans that amyloid deposition facilitates tau spread along connected pathways and memory decline.

Heidi I. L. Jacobs
Trey Hedden
Keith A. Johnson
Research05 Feb 2018
Nature Neuroscience

Volume: 21, P: 424-431
Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain

Bueichekú et al. use multimodal in vivo neuroimaging to investigate the brain characteristics of individuals presenting unawareness of memory loss who are at risk of Alzheimer’s disease due to age. They find unawareness of memory decline is an early behavioral sign that a person might develop Alzheimer’s disease.

Elisenda Bueichekú
Ibai Diez
Patrizia Vannini
ResearchOpen Access05 Apr 2024
Communications Medicine

Volume: 4, P: 1-13
Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid

Gagliardi, Rodriguez-Vieitez et al. image brain microstructural changes over time in cognitively-normal older adults. Cortical mean diffusivity was associated with accumulation of tau and episodic memory decline in those with amyloid deposits.

Geoffroy Gagliardi
Elena Rodriguez-Vieitez
Patrizia Vannini
ResearchOpen Access01 Aug 2023
Communications Medicine

Volume: 3, P: 1-10
Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models

Alexandra G. O’Neill
Melissa Pax
Hamdi Eryilmaz
ResearchOpen Access04 Jun 2025
NPP—Digital Psychiatry and Neuroscience

Volume: 3, P: 1-8
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals

Yun Jeong Hong
Chan-Mi Kim
Jorge Sepulcre
ResearchOpen Access22 Aug 2022
Scientific Reports

Volume: 12, P: 1-8
Divergent connectomic organization delineates genetic evolutionary traits in the human brain

Elisenda Bueichekú
Jose M. Gonzalez-de-Echavarri
Jorge Sepulcre
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption

Federico d’Oleire Uquillas
Esra Sefik
Jesse Gomez
Research11 Oct 2024
Molecular Psychiatry

Volume: 30, P: 1558-1572
Network hub centrality and working memory performance in schizophrenia

Hamdi Eryilmaz
Melissa Pax
Joshua L. Roffman
ResearchOpen Access23 Sept 2022
Schizophrenia

Volume: 8, P: 1-9
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults

Elena Rodriguez-Vieitez
Victor Montal
Patrizia Vannini
ResearchOpen Access29 Sept 2021
Molecular Psychiatry

Volume: 26, P: 7813-7822
Early-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder

Ibai Diez
Anna G. Larson
David L. Perez
Research12 Feb 2020
Molecular Psychiatry

Volume: 26, P: 3817-3828
Partial volume correction for PET quantification and its impact on brain network in Alzheimer’s disease

Jiarui Yang
Chenhui Hu
Quanzheng Li
ResearchOpen Access12 Oct 2017
Scientific Reports

Volume: 7, P: 1-14

Search

Filter By:

Search

Quick links