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Showing 1–3 of 3 results
Advanced filters: Author: Joris H. Hageman Clear advanced filters

  • Intestinal tuft cell subtypes represent successive stages of differentiation that is driven by crypt-villus signaling gradients. Here, the authors show that applying these gradients to organoids generates mature immune-related chemosensory tuft cells suitable for experimental studies.

    • Julian R. Buissant des Amorie
    • Max A. Betjes
    • Hugo J. G. Snippert
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Mismatch repair-deficient colorectal cancer clones adapt their mutation landscape by toggling homopolymer sequences in MutS homolog 3 (MSH3) and MutS homolog 6 (MSH6). This increases the subclonal mutation rate and clonal diversity, favoring immune escape and tumor growth.

    • Hamzeh Kayhanian
    • William Cross
    • Marnix Jansen
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1420-1433

  • Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal instability and can predict pan-cancer survival.

    • Erik van Dijk
    • Tom van den Bosch
    • Daniël M. Miedema
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12