Caused by a compromised lymphatic system, lymphoedema leads to fluid retention and tissue swelling, and is treated primarily with physical therapy. Here the authors present a metabolic approach to reduce lymphoedema by providing the ketone body β-hydroxybutyrate or by feeding ketogenic diet, which increases lymphangiogenesis and reduces fluid retention in mice.
- Melissa García-Caballero
- Annalisa Zecchin
- Peter Carmeliet
