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Showing 1–2 of 2 results
Advanced filters: Author: Jorunn Stamnaes Clear advanced filters

  • Dermatitis herpetiformis, a skin manifestation of the gluten-sensitive condition celiac disease, is hallmarked by autoantibody production to transglutaminase 3. Here, the authors present the 3D-structures of an autoantibody bound to transglutaminase 3 with an inhibitor mimicking a gluten-peptide substrate.

    • Julie Elisabeth Heggelund
    • Saykat Das
    • Ludvig M. Sollid
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • IgA antibodies directed against tissue transglutaminase 2 (TG2) are used as a serological marker of celiac disease. Ludvig M. Sollid and his colleagues provide an unbiased and thorough characterization of the mucosal antibody response directly from the effector compartment. They report that TG2-specific plasma cells are expanded in the duodenal mucosa of individuals with celiac disease. Antibodies cloned from these cells are of high affinity, show a restricted repertoire and minimal somatic hypermutation, and do not inhibit TG2 enzymatic activity.

    • Roberto Di Niro
    • Luka Mesin
    • Ludvig M Sollid
    Research
    Nature Medicine
    Volume: 18, P: 441-445