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Showing 1–6 of 6 results
Advanced filters: Author: Josée Dostie Clear advanced filters

  • A key step for the use of CRISPR-Cas9 in any study is the design of the guide RNA, however the underlying principles are still poorly understood. Here the authors show that multiple protospacer adjacent motif sequences are refractory to efficient targeting and repair.

    • Abba Malina
    • Christopher J. F. Cameron
    • Jerry Pelletier
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-6

  • Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 expression, which promotes vulnerability of these cancers to CDK4/6 inhibition.

    • Yibo Xue
    • Brian Meehan
    • Sidong Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability is driven by cyclin D1 deficiency induced by SMARCA4 loss.

    • Yibo Xue
    • Brian Meehan
    • Sidong Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • A technique called genome architecture mapping (GAM) involves sequencing DNA from a large number of thin nuclear cryosections to develop a map of genome organization without the limitations of existing 3C-based methods.

    • Robert A. Beagrie
    • Antonio Scialdone
    • Ana Pombo
    Research
    Nature
    Volume: 543, P: 519-524

  • Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants with large effects on BMD and fractures were identified near the EN1 locus and mouse studies confirmed this gene has an important role in skeletal biology.

    • Hou‐Feng Zheng
    • Vincenzo Forgetta
    • J. Brent Richards
    Research
    Nature
    Volume: 526, P: 112-117