The novel oral anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban have been examined for efficacy and safety in the prophylaxis and treatment of venous thromboembolism. In this Review, these clinical trials are summarized, and practical considerations in the use of these drugs are discussed.
- John N. Makaryus
- Jonathan L. Halperin
- Joe F. Lau