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Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.

Julien Chilloux
Francois Brial
Marc-Emmanuel Dumas
ResearchOpen Access08 Dec 2025
Nature Metabolism

Volume: 7, P: 2531-2547
Defective Olfactomedin-2 connects adipocyte dysfunction to obesity

Olfactomedin-2 is a pleiotropic glycoprotein emerging as a regulator of energy homeostasis via the hypothalamus. The present findings functionally connect adipose-specific OLFM2 to obesity, and highlight its significance in maintaining adipocyte commitment to avoid metabolic disease.

Aina Lluch
Jèssica Latorre
Francisco J. Ortega
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-25
Correction: Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

Nicholas M Morton
Jasmina Beltram
Simon Horvat
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 525
Irisin, the metabolic syndrome and follistatin in humans

Many important associations have been found between the newly discovered myokine irisin and measures of metabolic disease. However, not much is known regarding the role of irisin in human disease. Two recent reports now identify novel metabolic associations for this molecule in humans.

Pontus A. Boström
José Manuel Fernández-Real
News & Views19 Nov 2013
Nature Reviews Endocrinology

Volume: 10, P: 11-12
Central nicotine induces browning through hypothalamic κ opioid receptor

Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.

Patricia Seoane-Collazo
Laura Liñares-Pose
Miguel López
ResearchOpen Access06 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence

Plakophilin-2 is a key component of desmosomes required to maintain cardiac tissue cohesion. Here the authors uncover a previously unknown defect in cell cycle and adipocyte senescence due to impaired Plakophilin-2 in subjects with obesity.

Aina Lluch
Jessica Latorre
Francisco J. Ortega
ResearchOpen Access22 Aug 2023
Nature Communications

Volume: 14, P: 1-21
Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Metabolic activity of specific human gut microorganisms contributes to liver steatosis in obese women.

Lesley Hoyles
José-Manuel Fernández-Real
Marc-Emmanuel Dumas
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 1070-1080
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

Genetic analysis in mice selected for leanness has identified thiosulfate sulfurtransferase as a target for the treatment of diabetes.

Nicholas M Morton
Jasmina Beltram
Simon Horvat
Research06 Jun 2016
Nature Medicine

Volume: 22, P: 771-779
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β

Romero et al. show that the autophagy regulator TP53INP2 represses adipogenesis by promoting GSK3β sequestration and activation of β-catenin through an autophagy-dependent and ESCRT-dependent mechanism.

Montserrat Romero
Alba Sabaté-Pérez
Antonio Zorzano
Research28 Mar 2018
Nature Cell Biology

Volume: 20, P: 443-454
Publisher Correction: Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Lesley Hoyles
José-Manuel Fernández-Real
Marc-Emmanuel Dumas
Amendments and Corrections09 Aug 2018
Nature Medicine

Volume: 24, P: 1628
Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

Nicotinamide N-methyltransferase acts through its product, N¹-methylnicotinamide, to stabilize Sirt1 and thus regulate hepatic glucose and lipid metabolism.

Shangyu Hong
Jose M Moreno-Navarrete
Pavlos Pissios
Research13 Jul 2015
Nature Medicine

Volume: 21, P: 887-894
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Indoleamine 2,3-dioxygenase normally suppresses inflammation, but knockout of its gene is metabolically beneficial as its depletion reshapes the gut microbiota.

Ludivine Laurans
Nicolas Venteclef
Soraya Taleb
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 1113-1120
Soluble receptors for advanced glycation endproducts are predictors of insulin sensitivity and affected by weight loss

José María Moreno-Navarrete
Yenny Leal
José Manuel Fernández-Real
ResearchOpen Access19 Oct 2024
Nutrition & Diabetes

Volume: 14, P: 1-7
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

A randomized clinical trial reveals that the antidiabetic effects of metformin are at least partially due to beneficial changes in the microbiota.

Hao Wu
Eduardo Esteve
Fredrik Bäckhed
Research22 May 2017
Nature Medicine

Volume: 23, P: 850-858
The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism

Patients with obesity-associated metabolic dysfunction exhibit dysregulation in iron homeostasis and alterations in gut microbiota composition and functionality. This Review discusses the bidirectional relationships between the host and the microbiota in the acquisition of elemental iron and the implications for glucose metabolism.

Jordi Mayneris-Perxachs
José María Moreno-Navarrete
José Manuel Fernández-Real
Reviews19 Aug 2022
Nature Reviews Endocrinology

Volume: 18, P: 683-698
Morbidly obese subjects show increased serum sulfide in proportion to fat mass

Ferran Comas
Jèssica Latorre
José María Moreno-Navarrete
Research10 Oct 2020
International Journal of Obesity

Volume: 45, P: 415-426
Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function

Ferran Comas
Aina Lluch
José María Moreno-Navarrete
Research11 Sept 2018
International Journal of Obesity

Volume: 43, P: 1611-1619
Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism

José María Moreno-Navarrete
Amaia Rodríguez
José Manuel Fernández-Real
ResearchOpen Access13 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3

Peng Tang
Sam Virtue
Yongliang Zhang
ResearchOpen Access05 Jun 2021
Cell Death & Differentiation

Volume: 28, P: 3022-3035
Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

J M Moreno-Navarrete
M Manco
J M Fernández-Real
Research01 Dec 2009
International Journal of Obesity

Volume: 34, P: 240-249

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