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Showing 1–3 of 3 results
Advanced filters: Author: Joseph A. Chemler Clear advanced filters

  • The [4Fe4S]2+ cluster-containing DNA-repair enzyme MUTYH helps safeguard the integrity of Watson–Crick base pairing and the human genetic code. The MUTYH [4Fe4S]2+ cluster mediates DNA redox signalling and DNA lesion identification. Now, a MUTYH pathologic variant associated with catastrophic [4Fe4S]2+ cluster redox degradation, impairment of DNA signalling and human colonic tumorigenesis has been identified.

    • Kevin J. McDonnell
    • Joseph A. Chemler
    • Stephen B. Gruber
    Research
    Nature Chemistry
    Volume: 10, P: 873-880

  • Polyketide synthases are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to establish the structure of a bacterial full-length module, and to elucidate the structural basis of both intramodule and intermodule substrate transfer.

    • Somnath Dutta
    • Jonathan R. Whicher
    • Georgios Skiniotis
    Research
    Nature
    Volume: 510, P: 512-517

  • Polyketide synthases (PKSs) are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to probe the structure of an intact module of a multi-enzyme PKS in different functional states.

    • Jonathan R. Whicher
    • Somnath Dutta
    • Georgios Skiniotis
    Research
    Nature
    Volume: 510, P: 560-564