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Showing 1–4 of 4 results
Advanced filters: Author: Joseph A. Zundell Clear advanced filters

  • Nacarelli et al. show that the nicotinamide-phosphoribosyltransferase-regulated NAD+ biogenesis pathway promotes the proinflammatory senescence-associated secretory phenotype by enhancing glycolysis and mitochondrial respiration during senescence.

    • Timothy Nacarelli
    • Lena Lau
    • Rugang Zhang
    Research
    Nature Cell Biology
    Volume: 21, P: 397-407

  • The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.

    • Jianhuang Lin
    • Heng Liu
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.

    • Bo Zhao
    • Jianhuang Lin
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13