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Multiple Proteolytic Enzymes in the Human Mast Cells

NORMAN ENDE
YUTAKA KATAYAMA
JOSEPH V. AUDITORE
Research21 Mar 1964
Nature

Volume: 201, P: 1197-1198
Comments and Suggestions for Improvement of the Archon Genomics X PRIZE Validation Protocol

Alexander Wait Zaranek
Tom Clegg
Joseph Thakuria
ResearchOpen Access09 Mar 2011
Nature Precedings

P: 1
A functional map of HIV-host interactions in primary human T cells

Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.

Joseph Hiatt
Judd F. Hultquist
Nevan J. Krogan
ResearchOpen Access01 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment

GEORGE E. MILO JR
JOSEPH A. DIPAOLO
Research01 Sept 1978
Nature

Volume: 275, P: 130-132
Production of High Solids Tomatoes Through Molecular Modification of Levels of the Plant Growth Regulator Cytokinin

Belinda Martineau
Kristin R. Summerfelt
Joseph W. DeVerna
Research01 Mar 1995
Bio/Technology

Volume: 13, P: 250-254
Erratum: Haplotype-resolved genome sequencing of a Gujarati Indian individual

Jacob O Kitzman
Alexandra P MacKenzie
Jay Shendure
Amendments and Corrections06 May 2011
Nature Biotechnology

Volume: 29, P: 459
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Of 12 serology assays tested, four detect antibodies in more than 80% of patients with COVID-19.

Jeffrey D. Whitman
Joseph Hiatt
Alexander Marson
Research27 Aug 2020
Nature Biotechnology

Volume: 38, P: 1174-1183
Author Correction: A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

Anna-Lisa Doebley
Minjeong Ko
Gavin Ha
Amendments and CorrectionsOpen Access25 Jan 2023
Nature Communications

Volume: 14, P: 1
Evolution of enhanced innate immune evasion by SARS-CoV-2

The SARS-CoV-2 Alpha variant suppresses innate immune responses more effectively than isolates of first-wave SARS-CoV-2, and this is a result of mutations outside of the spike coding region that lead to upregulation of viral innate immune antagonists.

Lucy G. Thorne
Mehdi Bouhaddou
Nevan J. Krogan
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 487-495
Massively parallel functional dissection of mammalian enhancers in vivo

Two groups describe approaches for synthesizing and assaying the function of thousands of variants of mammalian DNA regulatory elements. Melnikov et al. use their results to engineer short optimized regulatory elements in human cells, whereas Patwardhan et al. study enhancers hundreds of bases long in mice.

Rupali P Patwardhan
Joseph B Hiatt
Jay Shendure
Research26 Feb 2012
Nature Biotechnology

Volume: 30, P: 265-270
COMPARISON OF RDS NEONATAL MORTALITY IN SEVERAL URBAN NICUs FROM A TRANSPORTED POPULATION

Anantham Harin
Angelo Ferrara
Joseph Dancis
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 534
Haplotype-resolved genome sequencing of a Gujarati Indian individual

Sequencing a human genome using next-generation methods does not distinguish between the two copies of each chromosome. Kitzman et al. determine a haplotype-resolved genome sequence by efficiently constructing and sequencing long-insert clones that cover the diploid genome with a low likelihood of overlap.

Jacob O Kitzman
Alexandra P MacKenzie
Jay Shendure
Research01 Jan 2011
Nature Biotechnology

Volume: 29, P: 59-63
Parallel, tag-directed assembly of locally derived short sequence reads

Short sequence reads are grouped based on the long genomic fragments from which they derive, enabling efficient local assembly of the long fragments and therefore accurate de novo genome assembly and metagenome sequencing.

Joseph B Hiatt
Rupali P Patwardhan
Jay Shendure
Research17 Jan 2010
Nature Methods

Volume: 7, P: 119-122
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

David E. Gordon
Gwendolyn M. Jang
Nevan J. Krogan
Research30 Apr 2020
Nature

Volume: 583, P: 459-468
A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

Nucleosome profiling from cell-free DNA (cfDNA) represents a potential approach for cancer detection and classification. Here, the authors develop Griffin, a computational framework for tumour subtype classification based on cfDNA nucleosome profiling that can work with ultra-low pass sequencing data.

Anna-Lisa Doebley
Minjeong Ko
Gavin Ha
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-18
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

Antibody responses are impaired during HIV-1 infection. Cicala and colleagues show that the HIV-1 glycoprotein gp120 directly impairs B cell function by promoting expression of TGF-β and the inhibitory receptor FcRL4.

Katija Jelicic
Raffaello Cimbro
Anthony S Fauci
Research27 Oct 2013
Nature Immunology

Volume: 14, P: 1256-1265
Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells

A machine learning model based on data from primary human T cells accurately predicts repair outcomes after CRISPR–Cas9 editing.

Ryan T. Leenay
Amirali Aghazadeh
James Zou
Research29 Jul 2019
Nature Biotechnology

Volume: 37, P: 1034-1037
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

William T Poueymirou
Wojtek Auerbach
David M Valenzuela
ResearchOpen Access24 Dec 2006
Nature Biotechnology

Volume: 25, P: 91-99
Reprogramming human T cell function and specificity with non-viral genome targeting

A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

Theodore L. Roth
Cristina Puig-Saus
Alexander Marson
Research11 Jul 2018
Nature

Volume: 559, P: 405-409
Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

Aftab Ansari and his colleagues show that antibody-mediated masking of α4β7 integrin impedes intravaginal transmission of simian immunodeficiency virus in macaques.

Siddappa N Byrareddy
Brianne Kallam
Aftab A Ansari
Research24 Nov 2014
Nature Medicine

Volume: 20, P: 1397-1400
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

Haplotype-resolved whole-genome sequencing of the HeLa CCL-2 strain shows that HeLa is relatively stable in terms of point variation; integration of several data sets reveals strong, haplotype-specific activation of the proto-oncogene MYC by the human papilloma virus type 18 genome, and enables the relationship between gene dosage and expression to be examined.

Andrew Adey
Joshua N. Burton
Jay Shendure
Research07 Aug 2013
Nature

Volume: 500, P: 207-211
Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster

Brian Oliver, Jason Lieb, Christine Disteche and colleagues present an analysis of expression data in mammals, C. elegans and Drosophila. They conclude that dosage compensation corrects the imbalance in the number of X chromosomes relative to autosomes by upregulating X-linked genes in both males and females.

Xinxian Deng
Joseph B Hiatt
Christine M Disteche
Research23 Oct 2011
Nature Genetics

Volume: 43, P: 1179-1185
Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma

Martha Scott Tomlinson
Hudson P. Santos
Kelly Vogt
ResearchOpen Access17 Oct 2019
Journal of Perinatology

Volume: 40, P: 306-315
Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

Thomas M. O’Shea
Robert M. Joseph
Kelly Vogt
Research29 May 2018
Journal of Perinatology

Volume: 38, P: 908-916
Measuring social determinants of health in the All of Us Research Program

Samantha Tesfaye
Robert M. Cronin
Cheryl R. Clark
ResearchOpen Access16 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
MAdCAM costimulation through Integrin-α₄β₇ promotes HIV replication

Fatima Nawaz
Livia R. Goes
James Arthos
ResearchOpen Access06 Jun 2018
Mucosal Immunology

Volume: 11, P: 1342-1351
Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device

Annamaria Mocciaro et al. present LACIS, a method for identifying and selecting gene-edited clones using a microfluidic device. The authors apply LACIS to primary T cells after CRISPR-Cas9 editing of CXCR4 and show that selection of edited clones was possible within 10 days from initiation of gene editing.

Annamaria Mocciaro
Theodore L. Roth
Gregory Lavieu
ResearchOpen Access03 May 2018
Communications Biology

Volume: 1, P: 1-8
CRISPR–Cas9 genome engineering of primary CD4⁺ T cells for the interrogation of HIV–host factor interactions

In this protocol, the authors describe how to design, synthesize, and deliver CRISPR–Cas9 RNPs to primary CD4⁺ T cells for targeted gene knockout. They then show how the edited cells can be used for the analysis of host factors in HIV replication.

Judd F. Hultquist
Joseph Hiatt
Nevan J. Krogan
Protocols17 Dec 2018
Nature Protocols

Volume: 14, P: 1-27
Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research

Paulette D. Chandler
Cheryl R. Clark
Brian Ahmedani
ResearchOpen Access22 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
Early life antecedents of positive child health among 10-year-old children born extremely preterm

Jacqueline T. Bangma
Evan Kwiatkowski
Rebecca C. Fry
Research20 Apr 2019
Pediatric Research

Volume: 86, P: 758-765

Search

Multiple Proteolytic Enzymes in the Human Mast Cells

Comments and Suggestions for Improvement of the Archon Genomics X PRIZE Validation Protocol

A functional map of HIV-host interactions in primary human T cells

Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment

Production of High Solids Tomatoes Through Molecular Modification of Levels of the Plant Growth Regulator Cytokinin

Erratum: Haplotype-resolved genome sequencing of a Gujarati Indian individual

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Author Correction: A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

Evolution of enhanced innate immune evasion by SARS-CoV-2

Massively parallel functional dissection of mammalian enhancers in vivo

COMPARISON OF RDS NEONATAL MORTALITY IN SEVERAL URBAN NICUs FROM A TRANSPORTED POPULATION

Haplotype-resolved genome sequencing of a Gujarati Indian individual

Parallel, tag-directed assembly of locally derived short sequence reads

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

Reprogramming human T cell function and specificity with non-viral genome targeting

Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster

Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma

Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm

Measuring social determinants of health in the All of Us Research Program

MAdCAM costimulation through Integrin-α₄β₇ promotes HIV replication

Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device

CRISPR–Cas9 genome engineering of primary CD4⁺ T cells for the interrogation of HIV–host factor interactions

Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research

Early life antecedents of positive child health among 10-year-old children born extremely preterm

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