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Showing 1–5 of 5 results
Advanced filters: Author: Joseph E. Wedekind Clear advanced filters

  • Riboswitches contain an aptamer domain that recognizes a metabolite and an expression platform that regulates gene expression. Here the authors report the crystal structure of a preQ1-sensing riboswitch from Carnobacterium antarcticus that shows two metabolites in a single binding pocket.

    • Griffin M. Schroeder
    • Chapin E. Cavender
    • Joseph E. Wedekind
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • PreQ1, a metabolic precursor of the modified tRNA nucleotide queuosine, regulates expression of queuosine biosynthetic genes via two distinct classes of preQ1 riboswitch. Biochemical studies and the first X-ray crystal structure of a class II preQ1 riboswitch reveal how preQ1 recognizes this RNA motif and how it may regulate translation of downstream genes.

    • Joseph A Liberman
    • Mohammad Salim
    • Joseph E Wedekind
    Research
    Nature Chemical Biology
    Volume: 9, P: 353-355

  • The ways in which an RNA molecule folds to form structures can be crucial to its function, and so methods for studying RNA structures make an important contribution to understanding transcriptomes. Experimental approaches in this field are being advanced by coupling them to high-throughput sequencing.

    • Yue Wan
    • Michael Kertesz
    • Howard Y. Chang
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 641-655