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Advanced filters: Author: Joseph J. Topczewski Clear advanced filters

  • An approach to selectively manipulate the C–H bonds of alicyclic amines at sites remote to nitrogen is demonstrated by the synthesis of new derivatives of several bioactive molecules, including varenicline, a drug used to treat nicotine addiction.

    • Joseph J. Topczewski
    • Pablo J. Cabrera
    • Melanie S. Sanford
    Research
    Nature
    Volume: 531, P: 220-224

  • Operationally simple chemical reactions, termed click reactions, are widely used in many scientific fields. A streamlined synthesis of compounds called azides looks set to expand the role of click chemistry still further.

    • Joseph J. Topczewski
    • En-Chih Liu
    News & Views
    Nature
    Volume: 574, P: 42-43