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Showing 1–2 of 2 results
Advanced filters: Author: Joseph M. Josephides Clear advanced filters

  • Single-cell replication timing (scRT) studies in cancer are challenging due to genomic heterogeneity. Here, the authors develop MnM, a machine learning tool that can provide heterogeneity-resolved scRT profiles, and apply it to a large single-cell dataset that includes tumours, cell lines, and patient-derived xenografts.

    • Joseph M. Josephides
    • Chun-Long Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.

    • Stefano Gnan
    • Joseph M. Josephides
    • Chun-Long Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15