Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Joseph M. Paggi Clear advanced filters

  • Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.

    • Amal El Daibani
    • Joseph M. Paggi
    • Tao Che
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Cryo-EM structures of µ-opioid receptor complexes with two agonists coupled to molecular dynamics simulations and functional assays highlight distinct efficacy for G protein subtype activation and β-arrestin recruitment.

    • Qianhui Qu
    • Weijiao Huang
    • Georgios Skiniotis
    Research
    Nature Chemical Biology
    Volume: 19, P: 423-430

  • Ligands that activate GPCRs generally do so by stabilizing a particular conformation of the transmembrane helices. Here, the authors reveal a distinct activation mechanism where a ligand instead stabilizes a particular intracellular loop conformation.

    • Alexander S. Powers
    • Aasma Khan
    • Ron O. Dror
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Polarization measurements are reported for the blazar Mk501, revealing a degree of X-ray polarization that is more than twice the optical value and supporting the shock-accelerated energy-stratified electron population scenario.

    • Ioannis Liodakis
    • Alan P. Marscher
    • Silvia Zane
    ResearchOpen Access
    Nature
    Volume: 611, P: 677-681

  • A cryo-electron structure of the µ-opioid receptor in complex with the peptide agonist DAMGO and the inhibitory G protein Gi reveals structural determinants of its G protein-binding specificity.

    • Antoine Koehl
    • Hongli Hu
    • Brian K. Kobilka
    Research
    Nature
    Volume: 558, P: 547-552

  • Crystal structures and molecular simulations of the designed anion-conducting channelrhodopsin iC++ provide molecular insights that enable structure-based design of channelrhodopsins with desirable properties for use as optogenetic tools.

    • Hideaki E. Kato
    • Yoon Seok Kim
    • Karl Deisseroth
    Research
    Nature
    Volume: 561, P: 349-354