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Showing 1–2 of 2 results
Advanced filters: Author: Joseph Menassa Clear advanced filters

  • Apical membrane antigen-1 (AMA1) is important for Plasmodium parasite invasion, but surface polymorphisms in P. falciparum AMA1 hamper vaccine and antibody development. Here the authors identify a humanised single-domain antibody molecule, an i-body, that binds to AMA1 of all Plasmodium parasites examined and inhibits parasite invasion.

    • Dimuthu Angage
    • Jill Chmielewski
    • Michael Foley
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Sepsis is a biphasic disease characterized by an initial inflammatory phase, followed by a prolonged immunosuppression phase. Puthalakath and colleagues utilize a CRISPR-mediated mutagenesis screen to identify TREML4 as a regulator of sepsis-induced immunosuppression.

    • Christina Nedeva
    • Joseph Menassa
    • Hamsa Puthalakath
    Research
    Nature Immunology
    Volume: 21, P: 1585-1596