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Showing 1–4 of 4 results
Advanced filters: Author: Joseph R. Palmeri Clear advanced filters

  • Pecan is an important specialty crop that has experienced extensive interspecific hybridization and nearly-obligate outcrossing. Here, the authors assemble diploid genomes of four outbred genotypes, identify interspecific introgressions through comparative genomics analyses, and map QTLs associated with pest resistance.

    • John T. Lovell
    • Nolan B. Bentley
    • Jennifer J. Randall
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Understanding the pharmacokinetics of locally-injected drugs could aid in the design of immunotherapies to maximize their therapeutic effect. Here, by evaluating different IL-2 fusion proteins, the authors show that molecular weight and matrix binding affect anti-tumor immune response and report a pharmacokinetic framework to predict response to intratumoral IL-2 therapy.

    • Noor Momin
    • Joseph R. Palmeri
    • K. Dane Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Cytokine therapies have been used to treat cancer but are susceptible to adverse effects owing to the activation of systemic inflammatory pathways. Here the authors avoid this toxicity by developing CD45-targeted IL-12 and IL-15 immunocytokines that are effective in treating tumors in mice when dosed intratumorally.

    • Luciano Santollani
    • Laura Maiorino
    • Darrell J. Irvine
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1820-1829

  • Antibodies stimulating the T cell co-activator 4-1BB (CD137) do enhance anti-tumour T cell function, but their utility is hampered by on target, off tumor toxicity. Here authors show that anchoring anti-4-1BB to tumours via fusion with the collagen binding protein LAIR diminishes systemic dissemination of the drug, and they demonstrate a curative effect in a triple-combination-therapy that relieves regulatory T cell immunosuppression in a mouse model of cancer.

    • Joseph R. Palmeri
    • Brianna M. Lax
    • K. Dane Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19