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Showing 1–11 of 11 results
Advanced filters: Author: Joseph Ziller Clear advanced filters

  • Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

    • Lucia Trastulla
    • Georgii Dolgalev
    • Michael J. Ziller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-28

  • José Martín-Subero and colleagues report the whole-genome bisulfite sequencing of ten blood cell subpopulations representing the cellular stages during B cell differentiation. They find that early stages are characterized by enhancer demethylation and that neoplasms derived from B cell lineages undergo methylation changes in regions with dynamic methylation during normal differentiation.

    • Marta Kulis
    • Angelika Merkel
    • José I Martín-Subero
    Research
    Nature Genetics
    Volume: 47, P: 746-756

  • Nitric oxide, NO, has an unpaired electron and is widely used and studied in such diverse fields as biochemistry and atmospheric chemistry. Its radical nature means that singly charged species are common, but now two electrons have been added to give a radical dianion in an yttrium complex.

    • William J. Evans
    • Ming Fang
    • Jeffrey I. Zink
    Research
    Nature Chemistry
    Volume: 2, P: 644-647

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330

  • Astroblastoma (AB) is an uncommon brain tumour and its origin remains unknown. Here, the authors perform integrative molecular analysis of 35 AB-like tumours and provide evidence that these arise in the context of epigenetic and genetic changes in neural progenitors occurring during brain development.

    • Norman L. Lehman
    • Nathalie Spassky
    • Akshitkumar M. Mistry
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Chemical experiments on californium are stymied by isotope availability and radioactivity considerations, but are advanced here with synthesis and characterization of an organometallic complex.

    • Conrad A. P. Goodwin
    • Jing Su
    • Joseph W. Ziller
    Research
    Nature
    Volume: 599, P: 421-424

  • Helical motifs in dense inorganic solids have remained exceedingly scarce. Now a type of 1D van der Waals helical crystal, GaSeI, is presented that manifests the rare quasi-periodic Boerdijk–Coxeter helix motif.

    • Dmitri Leo Mesoza Cordova
    • Kenneth Chua
    • Maxx Q. Arguilla
    Research
    Nature Materials
    Volume: 23, P: 1347-1354

  • The s-orbital mixing into the spin-bearing d orbital associated with a molecular Lu(II) complex is shown to both reduce spin–orbit coupling and increase electron–nuclear hyperfine interactions, which substantially improves electron spin coherence. Combined with the potential to tune interactions through coordination chemistry, it makes this system attractive for quantum information applications.

    • Krishnendu Kundu
    • Jessica R. K. White
    • Stephen Hill
    Research
    Nature Chemistry
    Volume: 14, P: 392-397

  • Manipulating the topological phases of quantum materials is necessary to fully leverage their potential for future electronics. Here, the authors experimentally demonstrate the controllable transition from a weak to a strong topological insulator phase through the in-situ application of high strain.

    • Jinyu Liu
    • Yinong Zhou
    • Luis A. Jauregui
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11