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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the cytoplasm, triggering cGAS–STING activation and innate immune signalling.

Laura E. Newman
Sammy Weiser Novak
Gerald S. Shadel
Research08 Feb 2024
Nature Cell Biology

Volume: 26, P: 194-206
The cornea during spaceflight: a frontier in space medicine ophthalmology

Joshua Ong
Benjamin Soares
Andrew G. Lee
Comments & Opinion21 Jul 2024
Eye

Volume: 38, P: 3207-3209

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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

The cornea during spaceflight: a frontier in space medicine ophthalmology

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