Nature Search

Peripheral blood DNA methylation predicts the early onset of primary tumor in TP53 mutation carriers

Li-Fraumeni syndrome leads to an increased predisposition to tumour development. Here, the authors develop a support vector machine model to predict early cancer risk in individuals using peripheral blood DNA methylation profiles.

Vallijah Subasri
Benjamin Brew
Anna Goldenberg
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-12
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

There is lack of therapies targeting the PAX3-FOXO1 fusion oncogene in fusion-positive rhabdomyosarcoma (FP-RMS). Here, the authors identify and characterise an inhibitor with highest inhibition of histone lysine demethylase 3B that suppresses PAX3-FOXO1 activity in FP-RMS.

Yong Yean Kim
Berkley E. Gryder
Javed Khan
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-19
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

GPR61 is an orphan GPCR of interest for treatment of appetite disorders, such as obesity and cachexia. Here, the authors report structures of GPR61 in its active and inactive states, including with a G protein-competitive small molecule inverse agonist.

Joshua A. Lees
João M. Dias
Seungil Han
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-12
Global evolution of inflammatory bowel disease across epidemiologic stages

An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of inflammatory bowel disease, and models stage 4 progression.

Lindsay Hracs
Joseph W. Windsor
Gilaad G. Kaplan
ResearchOpen Access30 Apr 2025
Nature

Volume: 642, P: 458-466
Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression

Hirofumi Hiyama
Antonio Iavarone
Steven A Reeves
Research29 May 1997
Oncogene

Volume: 14, P: 2533-2542
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Molecular organization of the COG vesicle tethering complex

Vesicle tethering is the least well understood step of vesicular transport. The core conserved oligomeric Golgi (COG) vesicle tethering complex from yeast, consisting of the four essential subunits Cog1–4, is now reconstituted and characterized by negative stain EM and single particle analysis. The COG complex forms a y-shaped structure, whose central region and the distal regions of at least two legs all participate in interactions with other components of the intracellular trafficking machinery.

Joshua A Lees
Calvin K Yip
Frederick M Hughson
Research24 Oct 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1292-1297
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

The authors implement a collection of patient-derived xenograft tumors to test cancer drug responses.

Hui Gao
Joshua M Korn
William R Sellers
Research19 Oct 2015
Nature Medicine

Volume: 21, P: 1318-1325
Propagation of activity through the cortical hierarchy and perception are determined by neural variability

The authors reveal how the perception of optogenetic stimulation depends on the variability of background neural activity.

James M. Rowland
Thijs L. van der Plas
Adam M. Packer
ResearchOpen Access28 Aug 2023
Nature Neuroscience

Volume: 26, P: 1584-1594
Self-reported anticipated harm from drinking water across 141 countries

Perceptions of drinking water safety influence how people use and value water. Here, the authors find that 52.3% of adults across 141 countries self-report anticipating harm from drinking water.

Joshua D. Miller
Chad Staddon
Sera L. Young
ResearchOpen Access25 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Community-driven tree planting greens the neighbouring landscape

Joshua Buxton
Tom Powell
Timothy M. Lenton
ResearchOpen Access14 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
BNT162b vaccines protect rhesus macaques from SARS-CoV-2

BNT162b1 and BNT162b2 are two candidate mRNA vaccines against COVID-19 that elicit high virus-entry inhibition titres in mice, elicit high virus-neutralizing titres in rhesus macaques and protect macaques from SARS-CoV-2 challenge.

Annette B. Vogel
Isis Kanevsky
Ugur Sahin
Research01 Feb 2021
Nature

Volume: 592, P: 283-289
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma

PARP inhibitors are mainly used to treat BRCA1/2 mutated cancers. Here, the authors show that MYC amplified glioblastomas are sensitive to PARP inhibition due to CDK18 repression, which impairs ATR regulated homologous recombination repair, and that ATR inhibition sensitises glioblastomas to PARP inhibition.

Jian-Fang Ning
Monica Stanciu
Samuel D. Rabkin
ResearchOpen Access02 Jul 2019
Nature Communications

Volume: 10, P: 1-18
Evaluation of candidate vaccine approaches for MERS-CoV

Unmet need exists for a vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV). Here the authors report the establishment and evaluation, in mice and primates, of a series of MERS-CoV immunogens and show that they can serve as promising leads for vaccine development.

Lingshu Wang
Wei Shi
Barney S. Graham
ResearchOpen Access28 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease. They identify a low-frequency missense variant in ADCY7 that doubles risk of ulcerative colitis and detect a burden of very rare, damaging missense variants in known Crohn's disease risk genes.

Yang Luo
Katrina M de Lange
Carl A Anderson
Research09 Jan 2017
Nature Genetics

Volume: 49, P: 186-192
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

John Rioux, Andre Franke, Tom Karlsen and colleagues perform a fine-mapping study of the HLA region in Crohn's disease and ulcerative colitis. They identify a primary role for HLA-DRB1*01:03 in both diseases and find evidence of heterozygous advantage in protection against ulcerative colitis.

Philippe Goyette
Gabrielle Boucher
John D Rioux
Research05 Jan 2015
Nature Genetics

Volume: 47, P: 172-179
The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population

Alexandra Zirra
Kamalesh C. Dey
Alastair J. Noyce
ResearchOpen Access17 Jun 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Miles Parkes and colleagues report results of a large genome-wide association meta-analysis and replication study for Crohn's disease. They identify 30 new susceptibility loci for this inflammatory bowel disease and implicate several interesting candidate genes in disease pathogenesis.

Andre Franke
Dermot P B McGovern
Miles Parkes
Research21 Nov 2010
Nature Genetics

Volume: 42, P: 1118-1125
Global arthropod beta-diversity is spatially and temporally structured by latitude

A study on global arthropod biodiversity dynamics reveals that beta-diversity increased with latitude, distance, and time. Species replacement and richness difference patterns vary across regions, supporting global biodiversity expectations.

Mathew Seymour
Tomas Roslin
Paul D. N. Hebert
ResearchOpen Access08 May 2024
Communications Biology

Volume: 7, P: 1-11
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Delineating the molecular and phenotypic spectrum of the SETD1B-related syndrome

Marjolein J. A. Weerts
Kristina Lanko
Tahsin Stefan Barakat
ResearchOpen Access03 Aug 2021
Genetics in Medicine

Volume: 23, P: 2122-2137
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2

Search

Peripheral blood DNA methylation predicts the early onset of primary tumor in TP53 mutation carriers

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

Global evolution of inflammatory bowel disease across epidemiologic stages

Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Molecular organization of the COG vesicle tethering complex

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Propagation of activity through the cortical hierarchy and perception are determined by neural variability

Self-reported anticipated harm from drinking water across 141 countries

Community-driven tree planting greens the neighbouring landscape

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

A second update on mapping the human genetic architecture of COVID-19

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma

Evaluation of candidate vaccine approaches for MERS-CoV

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population

Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Global arthropod beta-diversity is spatially and temporally structured by latitude

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Delineating the molecular and phenotypic spectrum of the SETD1B-related syndrome

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

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