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Showing 1–5 of 5 results
Advanced filters: Author: Joshua Bloomekatz Clear advanced filters

  • An impressive combination of computational modelling and experimental techniques in live zebrafish embryos reveals how the heart initiates its organized and rhythmic beating.

    • Joshua Bloomekatz
    • Neil C. Chi
    News & Views
    Nature
    Volume: 622, P: 37-39

  • Xu and colleagues show that the transcription factor Hand2 promotes pdgfra expression during early cardiogenesis and that it can do so independently of direct DNA binding by interacting with Tcf3.

    • Yanli Xu
    • Rupal Gehlot
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 3, P: 1531-1548

  • Destici, Zhu, et al. identify human-specific cis-regulatory elements (CREs) through a comparative epigenomic analysis of human and mouse cardiomyocytes at early stage of development and show that these CREs could contribute to species-specific cardiac features. Human-specific enhancers were particularly enriched in SNPs associated with human-specific traits (such as increased heart resting rate, atrial fibrillation and QRS duration), and the acquisition of human-specific enhancers could expand the functionality of the conserved transcriptional regulator ZIC3 by modifying its spatio-temporal expression.

    • Eugin Destici
    • Fugui Zhu
    • Neil C. Chi
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 830-843