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Showing 1–5 of 5 results
Advanced filters: Author: Joshua J. Breunig Clear advanced filters

  • The microenvironment of oesophageal squamous cell carcinomas (ESCC) is heterogeneous and can strongly impact response to treatment. Here, the authors characterize the ESCC tumour microenvironment with single-cell RNA-seq, finding CST1 + myofibroblasts with potential biological and prognostic significance as well as immunosuppression signatures.

    • Huy Q. Dinh
    • Feng Pan
    • En-Min Li
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Notch signalling is well known for its role in development, but here, Rakic and colleagues describe emerging aspects of Notch signalling in many processes in the adult brain. They propose that context-dependent crosstalk between Notch and various other signalling pathways underlies this pleiotropy.

    • Jessica L. Ables
    • Joshua J. Breunig
    • Pasko Rakic
    Reviews
    Nature Reviews Neuroscience
    Volume: 12, P: 269-283

  • Clinical and genetic phenotyping of consanguineous family cases of neonatal syndromic diabetes and type 2 diabetes, combined with in-depth functional studies in pluripotent stem cells, reveals a role for genetic variants of ONECUT1 in monogenic and multifactorial diabetes.

    • Anne Philippi
    • Sandra Heller
    • Alexander Kleger
    Research
    Nature Medicine
    Volume: 27, P: 1928-1940

  • Cilia are increasingly appreciated regulators of brain homeostasis. Several recent studies examine the cellular and molecular mechanisms of their biogenesis and orientation in ependymal cells.

    • Joshua J Breunig
    • Jon I Arellano
    • Pasko Rakic
    News & Views
    Nature Neuroscience
    Volume: 13, P: 654-655