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Showing 1–10 of 10 results
Advanced filters: Author: Joshua J. Krupp Clear advanced filters

  • Combining space topology and time topology, topological states that are localized simultaneously in space and time are theoretically and experimentally demonstrated, potentially enabling the space-time topological shaping of light waves with applications in spatiotemporal wave control for imaging, communications and topological lasers.

    • Joshua Feis
    • Sebastian Weidemann
    • Alexander Szameit
    ResearchOpen Access
    Nature Photonics
    Volume: 19, P: 518-525

  • The structure of a social network is thought to be heritable in many animals, including humans. Here, Rooke and colleagues identify a gene, which they name “degrees of kevin bacon (dokb)”, that is expressed in the central nervous system of Drosophila melanogaster and regulates the structure of social networks.

    • Rebecca Rooke
    • Joshua J. Krupp
    • Joel D. Levine
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

    • Barbara Franke
    • Jason L Stein
    • Patrick F Sullivan
    Research
    Nature Neuroscience
    Volume: 19, P: 420-431

  • Although ubiquitin ligases are known to control clock protein degradation, their other roles in clock neurons are unclear. Here the authors report that UBR4 promotes export of neuropeptides from the Golgi for axonal trafficking, which is important for circadian clock synchrony in mice and flies.

    • Sara Hegazi
    • Arthur H. Cheng
    • Hai-Ying Mary Cheng
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Expression of Drosophila or human endogenous retroviruses (ERVs) is sufficient to cause TDP-43 protein aggregation, and viral transmission of the ERVs triggers TDP-43 pathology in recipient cells. This mechanism may underly spread of neurodegenerative effects in a Drosophila model.

    • Yung-Heng Chang
    • Josh Dubnau
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The authors identified a protective genetic allele associated with lower PU.1 (SPI1) expression in myeloid cells by conducting a genome-wide scan of Alzheimer's disease (AD). PU.1 binds the promoters of AD-associated genes (e.g., CD33, MS4A4A & MS4A6A, TYROBP) and modulates their expression, suggesting it may reduce AD risk by regulating myeloid cell gene expression.

    • Kuan-lin Huang
    • Edoardo Marcora
    • Alison M Goate
    Research
    Nature Neuroscience
    Volume: 20, P: 1052-1061

  • Many organisms use chemical signals to indicate species and sex. Cuticular hydrocarbon signals are used by insects, including Drosophila melanogaster, to distinguish conspecific individuals from others, and they also contribute to courtship and mating interactions. Direct evidence is now provided that a single compound is used to communicate female identity among D. melanogaster, and to define a reproductive isolation barrier between D. melanogaster and sibling species.

    • Jean-Christophe Billeter
    • Jade Atallah
    • Joel D. Levine
    Research
    Nature
    Volume: 461, P: 987-991

  • David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

    • David C Whitcomb
    • Jessica LaRusch
    • Bernie Devlin
    Research
    Nature Genetics
    Volume: 44, P: 1349-1354