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Showing 1–3 of 3 results
Advanced filters: Author: Joshua J. Neumiller Clear advanced filters
  • Targeting incretins is emerging as an effective approach to treat cardiovascular–kidney–metabolic syndrome. Here, the authors examine the biological effects of incretins and other metabolic hormones, such as glucagon and amylin, as well as discussing current clinical data demonstrating the organ-protective effects of incretin drugs and their potential underlying mechanisms.

    • Radica Z. Alicic
    • Joshua J. Neumiller
    • Katherine R. Tuttle
    Reviews
    Nature Reviews Nephrology
    P: 1-18
  • In a retrospective cohort study examining the comparative effectiveness of diabetes drugs in adults at moderate risk for cardiovascular disease, GLP-1 receptor agonists and SGLT2 inhibitors reduced the risk of cardiovascular events compared to DPP4 inhibitors, whereas sulfonylureas increased the risk.

    • Rozalina G. McCoy
    • Jeph Herrin
    • Eric C. Polley
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 431-440
  • Clinical trials have demonstrated that glucagon-like peptide 1 receptor (GLP1R) agonists have therapeutic benefits beyond glycaemic control. Here, the authors examine the protective effects of incretin-based therapies in patients with diabetic kidney disease and how the immunomodulatory and anti-inflammatory effects of GLP1 might underlie this protection.

    • Radica Z. Alicic
    • Emily J. Cox
    • Katherine R. Tuttle
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 227-244