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Showing 1–4 of 4 results
Advanced filters: Author: Joshua J. Rennick Clear advanced filters

  • Our understanding of cytosolic delivery is hindered by existing methods for quantification which suffer from being indirect and showing low sensitivity. Here the authors report a SLEEQ (Split Luciferase Endosomal Escape Quantification) assay to assess cytosolic delivery of cell-penetrating peptides.

    • Serena L. Y. Teo
    • Joshua J. Rennick
    • Colin W. Pouton
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Measuring sub-cellular pH with high accuracy and spatiotemporal resolution remains challenging. Here, Johnston and co-workers develop a pH biosensor that combines the pH dependant fluorescent lifetime of mApple with deep learning to accurately determine sub-cellular pH in individual vesicles.

    • Joshua J. Rennick
    • Cameron J. Nowell
    • Angus P. R. Johnston
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Determining the trafficking of intracellular material is commonly done by colocalisation analysis using microscopy. Here the authors monitor trafficking of select cargo by measuring the conversion of quenched SNAP-tag substrates by subcellularly-localised SNAP-tag and detection by flow cytometry.

    • Laura I. FitzGerald
    • Luigi Aurelio
    • Angus P. R. Johnston
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Successful nanomedicine approaches rely on the efficient cellular uptake of nanoparticles, yet endocytic mechanisms remain challenging to probe. In this Review the authors describe the different cellular endocytic pathways and provide a critical discussion of the available tools and systems for their study.

    • Joshua J. Rennick
    • Angus P. R. Johnston
    • Robert G. Parton
    Reviews
    Nature Nanotechnology
    Volume: 16, P: 266-276