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Showing 1–3 of 3 results
Advanced filters: Author: Joshua P. Thaler Clear advanced filters

  • Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity.

    • Mauricio D. Dorfman
    • Jordan E. Krull
    • Joshua P. Thaler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • The gut prevents nutrient overload during a meal by promoting satiety and enhancing insulin secretion. New findings show that nutrients in the gut also activate a neural circuit that increases insulin sensitivity.

    • Joshua P. Thaler
    • David E. Cummings
    News & Views
    Nature
    Volume: 452, P: 941-942