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Showing 1–4 of 4 results
Advanced filters: Author: Joshua S. Chappie Clear advanced filters

  • Dynamin is a protein that catalyses the fission of clathrin-coated endocytic vesicles from cellular membranes. To carry out fission, it must hydrolyse GTP. The mechanism by which it does so is unknown, although it does require dynamin's GTPase effector domain (GED). Here, the structure of a minimal GTPase–GED fusion protein constructed from human dynamin 1 is presented. The structure reveals the catalytic machinery and provides new insight into the mechanisms underlying dynamin-catalysed membrane fission.

    • Joshua S. Chappie
    • Sharmistha Acharya
    • Fred Dyda
    Research
    Nature
    Volume: 465, P: 435-440

  • The bacterial defense system McrBC is a two-component motor-driven nuclease complex that cleaves foreign DNA. Here, the authors present the structures of the GTP-specific AAA + motor protein McrB and two McrBC complexes and discuss the molecular mechanism of how McrC binding stimulates McrB GTP hydrolysis.

    • Yiming Niu
    • Hiroshi Suzuki
    • Joshua S. Chappie
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • A screen utilizing an environmental DNA library in Escherichia coli is used to identify Brig1, a previously unknown anti-phage defence system with homologues across distinct clades of bacteria.

    • Amer A. Hossain
    • Ying Z. Pigli
    • Luciano A. Marraffini
    ResearchOpen Access
    Nature
    Volume: 629, P: 410-416