Nature Search

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Geminin regulates DNA replication by binding CDT1 and preventing MCM helicase loading. Using a reconstituted system and structural modelling, the authors find geminin inhibits via steric clash with MCM, not by blocking the CDT1–MCM interface. Combined with CDK activity, it fully halts licensing.

Joshua Tomkins
Lucy V. Edwardes
Christian Speck
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-23
Response of mouse melanoma cells to melanocyte stimulating hormone

GLENDA WONG
JOHN PAWELEK
JOSHUA MOROWITZ
Research01 Mar 1974
Nature

Volume: 248, P: 351-354
Active crustal differentiation beneath the Rio Grande Rift

A link between post-thickening lithospheric extension and the differentiation of continental crust is implied by granulite conditions beneath the Rio Grande Rift, inferred from analysis of lower-crustal xenoliths and thermobarometric modelling.

Jacob H. Cipar
Joshua M. Garber
Andrew J. Smye
Research12 Oct 2020
Nature Geoscience

Volume: 13, P: 758-763
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

The loading of the replicative helicase MCM2-7 is vital for replication fork assembly. Here, the authors reconstituted human MCM2-7 loading and identified the roles of Cdc6 in complex resolution and cancer-associated mutations in Mcm3 recruitment.

Jennifer N. Wells
Lucy V. Edwardes
Christian Speck
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems

COVID-19 has impacted health systems unequally and widespread SARS-CoV-2 testing for community surveillance has been limited globally. This work in Malawi highlights how river and wastewater can be used to detect emerging SARS-CoV-2 waves, identify variants of concern, and provide an early warning system.

Kayla G. Barnes
Joshua I. Levy
Nicholas Feasey
ResearchOpen Access30 Nov 2023
Nature Communications

Volume: 14, P: 1-11
Genomic epidemiology reveals multiple introductions of Zika virus into the United States

Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.

Nathan D. Grubaugh
Jason T. Ladner
Kristian G. Andersen
Research24 May 2017
Nature

Volume: 546, P: 401-405
Zika virus evolution and spread in the Americas

One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.

Hayden C. Metsky
Christian B. Matranga
Pardis C. Sabeti
Research24 May 2017
Nature

Volume: 546, P: 411-415
The disparate impacts of college admissions policies on Asian American applicants

Joshua Grossman
Sabina Tomkins
Sharad Goel
ResearchOpen Access23 Feb 2024
Scientific Reports

Volume: 14, P: 1-10

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