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Showing 1–5 of 5 results
Advanced filters: Author: Journey Cole Clear advanced filters

  • To gain insights into the early immune dynamics of transcriptional changes during SARS-CoV-2 infection, Singh et al. provide longitudinal scRNA-Seq of the broncho-alveolar compartment of SARS-CoV-2 infected rhesus macaques. They observe an accumulation of a distinct macrophage population that possesses an interferon-driven innate anti-viral gene signature early during infection that correlates with viral clearance.

    • Dhiraj K. Singh
    • Ekaterina Aladyeva
    • Deepak Kaushal
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • BNT162b1 and BNT162b2 are two candidate mRNA vaccines against COVID-19 that elicit high virus-entry inhibition titres in mice, elicit high virus-neutralizing titres in rhesus macaques and protect macaques from SARS-CoV-2 challenge.

    • Annette B. Vogel
    • Isis Kanevsky
    • Ugur Sahin
    Research
    Nature
    Volume: 592, P: 283-289

  • Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.

    • Bruce A. Rosa
    • Mushtaq Ahmed
    • Shabaana A. Khader
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14