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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

Secretory autophagy (SA) plays a crucial role in neuroinflammation-driven neurodegeneration, through SKA2 and FKBP5. SKA2 regulation of SA can inhibit IL-1β release. Its dysfunction leads to neurodegeneration, and is linked to Alzheimer’s disease.

Jakob Hartmann
Thomas Bajaj
Nils C. Gassen
ResearchOpen Access25 Mar 2024
Nature Communications

Volume: 15, P: 1-20
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Lenos et al. report that the spatiotemporal regulation of stem cell functionality is not intrinsically determined but environmentally defined during tumour growth and drug response in colon cancer.

Kristiaan J. Lenos
Daniël M. Miedema
Louis Vermeulen
Research03 Sept 2018
Nature Cell Biology

Volume: 20, P: 1193-1202
Genome-wide transcriptomics of the amygdala reveals similar oligodendrocyte-related responses to acute and chronic alcohol drinking in female mice

Sharvari Narendra
Claudia Klengel
Junghyup Suh
ResearchOpen Access12 Nov 2022
Translational Psychiatry

Volume: 12, P: 1-12