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The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Tumor cells commonly express abnormally glycosylated glycoproteins such as MUC1. Burchell and colleagues show that tumor-specific MUC1-ST interacts with the lectin Siglec-9 on myeloid cells and induces their conversion into suppressive tumor-associated macrophages.

Richard Beatson
Virginia Tajadura-Ortega
Joy M Burchell
Research05 Sept 2016
Nature Immunology

Volume: 17, P: 1273-1281
Plasmid-mediated tissue invasiveness in Yersinia enterocolitica

Don L. Zink
James C. Feeley
Gerard A. O'Donovan
Research10 Jan 1980
Nature

Volume: 283, P: 224-226
Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Beatson et al. show that a sialylated tumour-associated glycoform of the mucin MUC1 induces the differentiation of monocytes into tumour-associated macrophages. These macrophages are found in breast cancer stroma and their presence is associated with poor prognosis.

Richard Beatson
Rosalind Graham
Joy M. Burchell
ResearchOpen Access04 Nov 2020
Communications Biology

Volume: 3, P: 1-15
Niacin: another look at an underutilized lipid-lowering medication

Niacin exerts several beneficial lipid-altering effects, including lowering the levels of atherogenic particles that contain apolipoprotein B and raising HDL cholesterol levels. This article reviews the utility of niacin including its mechanism of action, clinical trial data regarding cardiovascular outcomes, adverse effect profile and strategies to address these effects and improve compliance.

Julia C. Creider
Robert A. Hegele
Tisha R. Joy
Reviews21 Feb 2012
Nature Reviews Endocrinology

Volume: 8, P: 517-528
SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages

Wayne A. Schroder
Thiago D. Hirata
Andreas Suhrbier
ResearchOpen Access27 Aug 2019
Scientific Reports

Volume: 9, P: 1-15
Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Pilar Mendoza
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature

Volume: 561, P: 479-484
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

The immunogen RC1 facilitates recognition of the V3-glycan patch on the envelope of HIV-1 and elicits specific serological responses in mice and macaques, making it a possible priming immunogen for sequential vaccination strategies in humans.

Amelia Escolano
Harry B. Gristick
Michel C. Nussenzweig
Research29 May 2019
Nature

Volume: 570, P: 468-473
Author Correction: Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
Amendments and CorrectionsOpen Access13 May 2026
npj Digital Medicine

Volume: 9, P: 1
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

This Registered Report presents evidence from 87 countries and regions showing that brief emotion-regulation interventions consistently reduced negative emotions and increased positive emotions during the COVID-19 pandemic.

Ke Wang
Amit Goldenberg
Hannah Moshontz
Research02 Aug 2021
Nature Human Behaviour

Volume: 5, P: 1089-1110
Clonal CD4⁺ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation

A shared gene expression program associated with silencing HIV-1 transcription may be critical for persistence of reactivated latent CD4⁺ T cells in patients with HIV.

Lillian B. Cohn
Israel T. da Silva
Michel C. Nussenzweig
Research23 Apr 2018
Nature Medicine

Volume: 24, P: 604-609
High-throughput and single-cell T cell receptor sequencing technologies

This Review discusses methodological advances for high-throughput analysis of the TCR repertoire at bulk and single-cell resolution.

Joy A. Pai
Ansuman T. Satpathy
Reviews19 Jul 2021
Nature Methods

Volume: 18, P: 881-892
Author Correction: A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

Ke Wang
Amit Goldenberg
Hannah Moshontz
Amendments and Corrections24 Aug 2022
Nature Human Behaviour

Volume: 6, P: 1318-1319
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
The Psychological Science Accelerator’s COVID-19 rapid-response dataset

Erin M. Buchanan
Savannah C. Lewis
Maximilian A. Primbs
ResearchOpen Access11 Feb 2023
Scientific Data

Volume: 10, P: 1-15

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The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Plasmid-mediated tissue invasiveness in Yersinia enterocolitica

Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Niacin: another look at an underutilized lipid-lowering medication

SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

Author Correction: Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

Clonal CD4⁺ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation

High-throughput and single-cell T cell receptor sequencing technologies

Author Correction: A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

The Psychological Science Accelerator’s COVID-19 rapid-response dataset

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