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Advanced filters: Author: Joyce Bian Clear advanced filters

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of PRC2 to a subset of polycomb targets.

Wenqing Ren
Nicole Medeiros
Kavitha Sarma
ResearchOpen Access06 May 2020
Nature Communications

Volume: 11, P: 1-15
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia

A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.

Jorge J. Llibre-Guerra
M. Victoria Fernandez
Ellen Ziegemeier
Research10 Feb 2025
Nature Medicine

Volume: 31, P: 1267-1275
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

Proteomic analysis of cerebrospinal fluid from individuals with autosomal dominant Alzheimer’s disease reveals how this complex and chronic disease evolves over many decades.

Erik C. B. Johnson
Shijia Bian
John Ringman
ResearchOpen Access07 Aug 2023
Nature Medicine

Volume: 29, P: 1979-1988
Attenuation of Morphine Tolerance, Withdrawal-Induced Hyperalgesia, and Associated Spinal Inflammatory Immune Responses by Propentofylline in Rats

Vasudeva Raghavendra
Flobert Y Tanga
Joyce A DeLeo
Research08 Oct 2003
Neuropsychopharmacology

Volume: 29, P: 327-334
Sacituzumab govitecan as second-line treatment for metastatic triple-negative breast cancer—phase 3 ASCENT study subanalysis

Lisa A. Carey
Delphine Loirat
Javier Cortés
ResearchOpen Access09 Jun 2022
npj Breast Cancer

Volume: 8, P: 1-7