In this Review, Tsirigotakiet al. discuss recent biochemical, structural and mechanistic insights that have been gained into the consecutive steps of the general secretory (Sec) pathway. They focus on the architecture and dynamics of SecYEG and its regulation by ribosomes and SecA, and present current models of the mechanisms and energetics of the Sec-pathway-dependent secretion process in bacteria.
- Alexandra Tsirigotaki
- Jozefien De Geyter
- Spyridoula Karamanou
