Nature Search

Experimental models for cardiac regeneration

Ana Sánchez
María Eugenia Fernández
Javier García-Sancho
Research01 Mar 2006
Nature Clinical Practice Cardiovascular Medicine

Volume: 3, P: S29-S32
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

Bruce A. Morgan
Juan -Carlos Izpisúa-Belmonte
Clifford J. Tabin
Research16 Jul 1992
Nature

Volume: 358, P: 236-239
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

Loss of the metalloproteinase Adamts1 leads to aortic pathology in mice due to increased NOS2-dependent NO production. Decreased Adamts1 expression, associated with increased NOS2 expression, occurs in Marfan syndrome (MFS) mice and in MFS patients, and NOS2 inhibition prevents and reverses aortic pathology in MFS mice.

Jorge Oller
Nerea Méndez-Barbero
Juan Miguel Redondo
Research09 Jan 2017
Nature Medicine

Volume: 23, P: 200-212
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent protein kinase reverts MFS aortopathy in mice.

Andrea de la Fuente-Alonso
Marta Toral
Juan Miguel Redondo
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-18
The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry

Concepción Rodríguez Esteban
Javier Capdevila
Juan Carlos Izpisúa Belmonte
Research16 Sept 1999
Nature

Volume: 401, P: 243-251
DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos

Juan A. Montero
Cristina Sanchez-Fernandez
Juan M. Hurle
ResearchOpen Access18 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb

Cristina Sanchez-Fernandez
Carlos I. Lorda-Diez
Juan M. Hurlé
ResearchOpen Access25 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-14
Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death

Cristina Duarte-Olivenza
Goretti Moran
Juan A. Montero
ResearchOpen Access09 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-10
The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken

Sanchez-Fernandez, Lorda-Diez et al. study a possible link between DNA methylation and interdigital cell death. They use irradiation experiments, methylation, and mutagenic analyses to demonstrate that Dnmt3b inversely regulates cell death and cartilage differentiation. Their work provides insights on the regulation of apoptosis in embryonic limbs.

Cristina Sanchez-Fernandez
Carlos Ignacio Lorda-Diez
Juan Antonio Montero
ResearchOpen Access05 Jun 2020
Communications Biology

Volume: 3, P: 1-12
TGFβ2-induced senescence during early inner ear development

Alejandro Gibaja
María R. Aburto
Marta Magariños
ResearchOpen Access11 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
Unveiling the pathogen behind the vacuole

Following host cell invasion, many bacterial and parasitic pathogens hide from the immune system in an intracellular vacuolar niche. In this Opinion article, Mota and colleagues discuss how these 'professional' vacuolar pathogens can remain susceptible to recognition and clearance by the host.

Peter Liehl
Vanessa Zuzarte-Luis
Maria M. Mota
Reviews20 Jul 2015
Nature Reviews Microbiology

Volume: 13, P: 589-598

Search

Experimental models for cardiac regeneration

Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry

DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos

UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb

Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death

The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken

TGFβ2-induced senescence during early inner ear development

Unveiling the pathogen behind the vacuole

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