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Showing 1–5 of 5 results
Advanced filters: Author: Juan Pablo Couso Clear advanced filters

  • Short open reading frames (smORFs) of less than 100 codons exist in the thousands in metazoan genomes, mostly with yet unknown functions. Here the authors show how a smORF conserved from flies to vertebrates produces a secreted peptide that enhances the diffusion of the cell signalling protein Wingless.

    • Emile G. Magny
    • Ana Isabel Platero
    • Juan Pablo Couso
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • A comprehensive analysis of small open reading frames (smORFs) in flies, mice and humans supports their classification into different functional groups, from inert DNA sequences to transcribed and translated smORFs that have various activities. The different smORF classes could represent steps in gene, peptide and protein evolution.

    • Juan-Pablo Couso
    • Pedro Patraquim
    Research
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 575-589

  • Translation of 100 to 300 micropeptides from small ORFs within lncRNA was detected by Ribosomal Profiling in Drosophila embryos. These translated small ORFs showed natural selection conserving micropeptide sequence and function.

    • Pedro Patraquim
    • Emile G. Magny
    • Juan Pablo Couso
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15