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Publisher Correction: APOBEC3 mutagenesis drives therapy resistance in breast cancer

Avantika Gupta
Andrea Gazzo
Sarat Chandarlapaty
Amendments and CorrectionsOpen Access12 Dec 2025
Nature Genetics

Volume: 58, P: 232
RNA transcripts serve as a template for double-strand break repair in human cells

DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repair. This process can lead to intron deletion, resulting in a mutational signature in cancer genomes.

Manisha Jalan
Alessandra Brambati
Agnel Sfeir
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-16
APOBEC3 mutagenesis drives therapy resistance in breast cancer

Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated with mutations known to drive drug resistance.

Avantika Gupta
Andrea Gazzo
Sarat Chandarlapaty
ResearchOpen Access16 May 2025
Nature Genetics

Volume: 57, P: 1452-1462
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

Liquid biopsies allow the non-invasive detection of somatic mutations from tumours. Here, the authors develop and test MSK-ACCESS, an NGS-based clinical assay for identifying low frequency mutations in 129 genes and describe how it benefits patients in the clinic.

A. Rose Brannon
Gowtham Jayakumaran
Ryma Benayed
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-12
HER kinase inhibition in patients with HER2- and HER3-mutant cancers

In a basket trial design, the efficacy of the pan-HER kinase inhibitor neratinib is tested in patients with 21 different tumour types, and responses are determined by mutation and tissue type, and are restricted to HER2-mutant cancers.

David M. Hyman
Sarina A. Piha-Paul
David B. Solit
Research31 Jan 2018
Nature

Volume: 554, P: 189-194
Gut microbiomes of wild great apes fluctuate seasonally in response to diet

Microbiota composition fluctuates in response to changes in environmental and lifestyle factors. Here, Hicks et al. show that the faecal microbiota of wild gorillas and chimpanzees is temporally dynamic, with shifts that correlate with seasonal rainfall patterns and periods of high and low frugivory.

Allison L. Hicks
Kerry Jo Lee
Brent L. Williams
ResearchOpen Access03 May 2018
Nature Communications

Volume: 9, P: 1-18
Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers

David M. Hyman
Sarina A. Piha-Paul
David B. Solit
Amendments and Corrections12 Feb 2019
Nature

Volume: 566, P: E11-E12
Resistance to TRK inhibition mediated by convergent MAPK pathway activation

A subset of patients treated with selective TRK inhibitors (including the newly approved larotrectinib) develop off-target resistance mediated by genomic acquisition of MAPK pathway-activating alterations, and may benefit from combined targeted therapy.

Emiliano Cocco
Alison M. Schram
Maurizio Scaltriti
Research12 Aug 2019
Nature Medicine

Volume: 25, P: 1422-1427

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