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Publisher Correction: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

Susanne C. van den Brink
Anna Alemany
Alexander van Oudenaarden
Amendments and Corrections05 Mar 2020
Nature

Volume: 579, P: E11
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

The authors use three-dimensional live-cell imaging of colorectal carcinoma organoids to show that chromosomal instability is widespread. Single-cell sequencing identifies heterogeneity of copy number alterations and shows clonal evolution.

Ana C. F. Bolhaqueiro
Bas Ponsioen
Geert J. P. L. Kops
Research29 Apr 2019
Nature Genetics

Volume: 51, P: 824-834
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.

Susanne C. van den Brink
Anna Alemany
Alexander van Oudenaarden
Research19 Feb 2020
Nature

Volume: 582, P: 405-409
Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Anti-androgen therapy inhibits prostate cancer (PC) progression, and is thought to act directly on cancer cells. Here the authors show that androgen receptor is expressed on normal and PC-associated macrophages, and its stimulation alters macrophage secretome to promote migration of cultured PC cell lines.

Bianca Cioni
Anniek Zaalberg
Andries M. Bergman
ResearchOpen Access09 Sept 2020
Nature Communications

Volume: 11, P: 1-17
Mapping the physical network of cellular interactions

The ProximID approach generates single-cell expression profiles and a network of enriched physical cellular interactions within a tissue.

Jean-Charles Boisset
Judith Vivié
Alexander van Oudenaarden
Research21 May 2018
Nature Methods

Volume: 15, P: 547-553
Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.

Florian Wimmers
Nikita Subedi
Jurjen Tel
ResearchOpen Access20 Aug 2018
Nature Communications

Volume: 9, P: 1-12
Blastocyst-like structures generated solely from stem cells

Trophoblast and embryonic stem cells interact in vitro to form structures that resemble early blastocysts, and the embryo provides signals that drive early trophectoderm development and implantation.

Nicolas C. Rivron
Javier Frias-Aldeguer
Niels Geijsen
Research02 May 2018
Nature

Volume: 557, P: 106-111

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Publisher Correction: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Mapping the physical network of cellular interactions

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Blastocyst-like structures generated solely from stem cells

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