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Showing 1–4 of 4 results
Advanced filters: Author: Judy Hess Clear advanced filters

  • Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

    • Xia Jiang
    • Hilary K. Finucane
    • Sara Lindström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-23

  • There are few available models to study neuroendocrine prostate cancer. Here they develop and characterize patient derived organoids from metastatic lesions, use these models to show the role of EZH2 in driving neuroendocrine phenotype, and perform high throughput organoid screening to identify therapeutic drug combinations.

    • Loredana Puca
    • Rohan Bareja
    • Himisha Beltran
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Genome-wide analyses identify variants near HDAC9 associated with abdominal aortic calcification and other cardiovascular phenotypes. Functional work shows that HDAC9 promotes an osteogenic vascular smooth muscle cell phenotype, enhancing calcification and reducing contractility.

    • Rajeev Malhotra
    • Andreas C. Mauer
    • Christopher J. O’Donnell
    Research
    Nature Genetics
    Volume: 51, P: 1580-1587