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Showing 1–2 of 2 results
Advanced filters: Author: Juebei Li Clear advanced filters

  • The mechanism underlying YAP/TAZ transactivation remains to be explored. Here the authors report that the hydrophobic transcriptional activation domains of YAP/TAZ exert dual functions on transcriptional initiation and elongation through interactions with TAF4 and MED15, which could be targeted for anti-cancer therapy.

    • Man Yu
    • Jingning Wang
    • Shuguo Sun
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Qin et al. find that cell detachment induces condensation of LATS2, a core kinase of the Hippo pathway. These LATS2 condensates protect LATS2 from degradation by the ubiquitin–proteasome system, thereby promoting the assembly of Hippo signalosomes for pathway activation.

    • Min Qin
    • Ershuo Geng
    • Shuguo Sun
    Research
    Nature Chemical Biology
    Volume: 20, P: 710-720