Ivaska and colleagues identify SHARPIN as an inhibitor of integrin activity in an RNAi screen for integrin regulators. They show that SHARPIN acts by binding to the cytoplasmic domain of integrin α-subunits and reduces the recruitment of talin and kindlin to the β-subunits.
- Juha K. Rantala
- Jeroen Pouwels
- Johanna Ivaska
