Nature Search

Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity

Many physical and mental disorders share common risk factors captured by a general disease factor. Here, the authors identify the neural, genetic, and environmental bases of this factor, linking environmental deprivation to brain structure and multimorbidity risk.

Jin Chen
Yuning Zhang
Jiaojian Wang
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health

Yuzhu Li
Barbara J. Sahakian
Jianfeng Feng
Amendments and Corrections09 May 2022
Nature Aging

Volume: 2, P: 453
Whole exome sequencing analysis identifies genes for alcohol consumption

The authors leverage whole exome sequencing data to investigate protein-coding variants associated with alcohol consumption. Phenome-wide association analyses reveal that alcohol consumption-related genes are associated with brain white matter integrity and risk of digestive and neuropsychiatric diseases.

Jujiao Kang
Yue-Ting Deng
Jianfeng Feng
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Atlas of proteomic signatures of brain structure and its links to brain disorders

The connection between plasma proteomic and brain structure remains unclear. Here, the authors establish a comprehensive atlas of the patterns of associations between microscale proteome and brain structure, and demonstrate their potential value for studying brain disorders.

Peng Ren
Xiao-He Hou
Wei Cheng
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals

Brain iron accumulation has been associated with multiple brain disorders, but the mechanism is not well understood. Here, the authors investigate the genetic determinants of brain iron accumulation and their implications for neuropsychiatric disorders.

Weikang Gong
Yan Fu
Jin-Tai Yu
ResearchOpen Access02 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Genetic associations of protein-coding variants in venous thromboembolism

Here, the authors perform a large exome-wide study for venous thromboembolism and identify 18 potential risk genes, including 4 new genes, revealing a significant role of rare coding variants, and offering insights into genetic risk factors.

Xiao-Yu He
Bang-Sheng Wu
Jin-Tai Yu
ResearchOpen Access01 Apr 2024
Nature Communications

Volume: 15, P: 1-12
Investigating grey matter volumetric trajectories through the lifespan at the individual level

Longitudinal analysis of neuroimaging data are useful for analysing heterogeneity in adolescent brain development. Here the authors cluster adolescent participants of the IMAGEN study into groups based on gray matter volume developmental patterns and investigate genome-wide and epigenome-wide associations with these groups.

Runye Shi
Shitong Xiang
Gunter Schumann
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-14
Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

This study reveals 246 behaviour-related and 200 physiological factors associated with genetic predisposition to suicide attempts. Mendelian randomization further indicates causal links for 58 factors.

Bei Zhang
Jia You
Jianfeng Feng
Research02 Jul 2024
Nature Human Behaviour

Volume: 8, P: 1784-1797
A shared neural basis underlying psychiatric comorbidity

Evidence from large longitudinal neuroimaging cohorts, which include genetic and behavioral data, suggest a common neural basis for symptoms seen across multiple psychiatric disorders.

Chao Xie
Shitong Xiang
Betteke Maria van Noort
ResearchOpen Access24 Apr 2023
Nature Medicine

Volume: 29, P: 1232-1242
Neuroimaging biomarkers define neurophysiological subtypes with distinct trajectories in schizophrenia

Using data-driven disease-progression modelling, Jiang, Wang, Zhou et al. characterized and replicated two distinct ‘trajectories’ of brain atrophy in patients with schizophrenia.

Yuchao Jiang
Jijun Wang
Jianfeng Feng
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 186-199
Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults

The genetic contributions of protein-coding variants to immune-mediated diseases (IMDs) have yet to be fully explored. Here, the authors conduct a large whole-exome association study, identifying 162 genes associated with 35 IMDs, including 124 that had not been previously reported.

Liu Yang
Ya-Nan Ou
Jin-Tai Yu
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-15
The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health

Change in sleep patterns is an important feature of the aging process. This study shows that sleep duration is nonlinearly associated with mental health and cognition measures in the 38- to 73-year-old population, with underlying brain and genetic mechanisms.

Yuzhu Li
Barbara J. Sahakian
Jianfeng Feng
Research28 Apr 2022
Nature Aging

Volume: 2, P: 425-437
Author Correction: A shared neural basis underlying psychiatric comorbidity

Chao Xie
Shitong Xiang
Betteke Maria van Noort
Amendments and CorrectionsOpen Access09 Aug 2023
Nature Medicine

Volume: 29, P: 2375
Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia

Yue Qin
Jujiao Kang
Xiaohong Gong
ResearchOpen Access21 Sept 2020
Translational Psychiatry

Volume: 10, P: 1-12
Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia

Xiaoqian Ma
Nana Feng
Qiang Luo
ResearchOpen Access22 Jan 2025
Translational Psychiatry

Volume: 15, P: 1-9
Large-scale proteomic analyses of incident Alzheimer’s disease reveal new pathophysiological insights and potential therapeutic targets

Yi Zhang
Yu Guo
JinTai Yu
Research19 Nov 2024
Molecular Psychiatry

Volume: 30, P: 2347-2361
Association between parental age, brain structure, and behavioral and cognitive problems in children

Jingnan Du
Edmund T. Rolls
Jianfeng Feng
Research14 Oct 2021
Molecular Psychiatry

Volume: 27, P: 967-975
Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning

Miao Chang
Fay Y. Womer
Fei Wang
ResearchOpen Access01 Oct 2020
Molecular Psychiatry

Volume: 26, P: 2991-3002
Correction: Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning

Miao Chang
Fay Y. Womer
Fei Wang
Amendments and CorrectionsOpen Access17 Nov 2020
Molecular Psychiatry

Volume: 26, P: 3003
Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence

Xiao Chang
Wei Zhao
Jianfeng Feng
ReviewsOpen Access12 Nov 2022
Schizophrenia

Volume: 8, P: 1-12

Search

Filter By:

Search

Quick links