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Showing 1–12 of 12 results
Advanced filters: Author: Jukka Jernvall Clear advanced filters

  • Gradual changes that occur to mammalian tooth morphology across evolutionary time were modelled in vitro and in vivo by modulation of signalling pathways in the mouse, and computer modelling was used to provide further analysis of the parameters influencing tooth morphology.

    • Enni Harjunmaa
    • Kerstin Seidel
    • Jukka Jernvall
    Research
    Nature
    Volume: 512, P: 44-48

  • Activation of EDA and activin A signalling, and inhibition of SHH signalling pathways together increase the number of cusps on cultured mouse cheek teeth, showing that a substantial increase in complexity requires multiple changes in developmental regulation.

    • Enni Harjunmaa
    • Aki Kallonen
    • Jukka Jernvall
    Research
    Nature
    Volume: 483, P: 324-327

  • Genotype and phenotype cannot be connected simply by one-to-one mapping; instead they are linked by the nonlinear process of development. Here, a computational model is described — based on real data about the development of seal teeth — that attempts to combine the three. The results show that a few genetic parameters regulating signalling during cusp development may explain variation among individuals. But a cellular parameter regulating epithelial growth may explain tooth-to-tooth variation along the jaw.

    • Isaac Salazar-Ciudad
    • Jukka Jernvall
    Research
    Nature
    Volume: 464, P: 583-586

  • A test-bed system for examining how development guides evolutionary change is the arrangement of molars in mice. The first molar is larger than the one behind, which is in turn larger than the third, hindmost molar. Experimental investigations have shown that molar development follows an inhibitory cascade model, and the results are used to show how this simple model governs the variation in molar size and number in rodent evolution.

    • Kathryn D. Kavanagh
    • Alistair R. Evans
    • Jukka Jernvall
    Research
    Nature
    Volume: 449, P: 427-432

  • Adaptive radiation of Mesozoic-era multituberculate mammals began at least 20 million years before the extinction of non-avian dinosaurs and continued across the Cretaceous–Paleogene boundary—probably as a result of dietary expansion towards herbivory during the ecological rise of angiosperms—and is supported by increases in generic richness and disparity in dental complexity and body size.

    • Gregory P. Wilson
    • Alistair R. Evans
    • Jukka Jernvall
    Research
    Nature
    Volume: 483, P: 457-460

  • Tooth shapes vary greatly amongst mammals, but the genetic underpinnings and functional relevance of new dental morphologies are largely unknown. Gomes Rodrigues et al. show that Eda and Edargenes modulate molar crest development in mice, enabling incipient adaptation to highly fibrous diets.

    • Helder Gomes Rodrigues
    • Sabrina Renaud
    • Laurent Viriot
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • Modern mammals are endothermic, but it has not been clear when this type of metabolism evolved. Here, Newham et al. analyse tooth and bone structure in Early Jurassic stem-mammal fossils to estimate lifespan and blood flow rates, which inform about basal and maximum metabolic rates, respectively, and show these stem-mammals had metabolic rates closer to modern ectothermic reptiles than to endothermic mammals.

    • Elis Newham
    • Pamela G. Gill
    • Ian J. Corfe
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The inhibitory cascade, an activator–inhibitor mechanism that affects relative tooth size in mammals, produces the default pattern of tooth sizes for all lower primary postcanine teeth in hominins.

    • Alistair R. Evans
    • E. Susanne Daly
    • Jukka Jernvall
    Research
    Nature
    Volume: 530, P: 477-480