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Showing 1–21 of 21 results
Advanced filters: Author: Juleen R. Zierath Clear advanced filters

  • In this Review, Romain Barrès and Juleen Zierath outline the current understanding of the mechanisms underlying how lifestyle factors affect epigenetic changes involved in the risk of type 2 diabetes mellitus. The latest findings on the mechanisms by which diet and exercise affect the epigenome are also discussed.

    • Romain Barrès
    • Juleen R. Zierath
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 441-451

  • Time restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies periodicity in amino acid related metabolites and transporters.

    • Leonidas S. Lundell
    • Evelyn B. Parr
    • John A. Hawley
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Exercise training is one of the key interventions for preventing and treating type 2 diabetes mellitus. Although the health-promoting effects of exercise are largely ascribed to improvements in skeletal muscle insulin sensitivity, new data published in Diabetes suggest 'exercise-trained' subcutaneous adipose tissue might also have an important role in enhancing glucose homeostasis.

    • Harriet Wallberg-Henriksson
    • Juleen R. Zierath
    News & Views
    Nature Reviews Endocrinology
    Volume: 11, P: 198-200

  • The pathways that underlie the effects of exercise on metabolism remain incompletely described. Here, the authors perform a meta-analysis of transcriptomic data from 66 published datasets of human skeletal muscle. They identify pathways selectively activated by inactivity, aerobic or resistance exercise, and characterize NR4A3 as one of the genes responsive to inactivity.

    • Nicolas J. Pillon
    • Brendan M. Gabriel
    • Juleen R. Zierath
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.

    • Zhe Wang
    • Andrew Emmerich
    • Marcel den Hoed
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1332-1344

  • Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

    • Christoffer Clemmensen
    • Zachary Gerhart-Hines
    • Kei Sakamoto
    Comments & Opinion
    Nature Metabolism
    Volume: 7, P: 1495-1497

  • Lecoutre, Maqdasy and Rizo-Roca show that whole-body pharmacological inhibition or adipocyte-specific deletion of glutaminase in mice activates thermogenesis in inguinal adipocytes and promotes metabolic health. They also link decreased plasma and adipose tissue glutamine-to-glutamate ratios to insulin resistance in humans with obesity.

    • Simon Lecoutre
    • Salwan Maqdasy
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 1329-1346

  • The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

    • Alexander S. Banks
    • David B. Allison
    • Juleen R. Zierath
    Reviews
    Nature Metabolism
    Volume: 7, P: 1765-1780

  • Exercise induces structural and functional adaptations in skeletal muscle that involve transcriptomic remodeling, including of miRNA expression. Here the authors examine the expression of miRNAs in human muscle following exercise training and investigate the functions of miR-19b-3p on glucose metabolism in cells and mouse muscle.

    • Julie Massart
    • Rasmus J. O. Sjögren
    • Anna Krook
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Maqdasy, Lecoutre et al. show that increased an phosphocreatine/creatine ratio in white adipocytes drives changes in AMP-activated protein kinase activity and promotes white adipocyte inflammation during obesity.

    • Salwan Maqdasy
    • Simon Lecoutre
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 190-202

  • Skeletal muscles show high metabolic flexibility and functional plasticity in their response to different exercise modalities. Recent findings have advanced our understanding of signalling, transcriptional and epigenetic mechanisms that regulate muscle adaptation to exercise and their impact on muscle physiology.

    • Jonathon A. B. Smith
    • Kevin A. Murach
    • Juleen R. Zierath
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 607-632

  • Exercise is used to prevent and treat metabolic diseases. Finding the optimum time for exercise is important as skeletal muscle has many clock-controlled genes. This Review summarizes the current literature regarding the consequence of exercise at different times of the day.

    • Brendan M. Gabriel
    • Juleen R. Zierath
    Reviews
    Nature Reviews Endocrinology
    Volume: 15, P: 197-206

  • An association mapping study of type-2-diabetes-related quantitative traits in the Greenlandic population identified a common variant in TBC1D4 that increases plasma glucose levels and serum insulin levels after an oral glucose load and type 2 diabetes risk, with effect sizes several times larger than any previous findings of large-scale genome-wide association studies for these traits.

    • Ida Moltke
    • Niels Grarup
    • Torben Hansen
    Research
    Nature
    Volume: 512, P: 190-193

  • Hadi Al-Hasani and colleagues report that a frameshift deletion in Tbc1d1 in lean SJL mice underlies a quantitative trait locus conferring protection against high-fat diet-induced obesity. TBC1D1 seems to influence metabolism by regulating fatty acid uptake and oxidation in skeletal muscle cells.

    • Alexandra Chadt
    • Katja Leicht
    • Hadi Al-Hasani
    Research
    Nature Genetics
    Volume: 40, P: 1354-1359

  • Exerkines are signalling moieties that are released in response to acute and/or chronic exercise that exert their effects through endocrine, paracrine and/or autocrine pathways. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

    • Lisa S. Chow
    • Robert E. Gerszten
    • Michael P. Snyder
    Reviews
    Nature Reviews Endocrinology
    Volume: 18, P: 273-289